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Daicel
Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible…
Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient mechanical stability. In order to meet these and other critical quality attributes (CQAs), quality by design is encouraged.…
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GRANFILLER-D™ Water Absorption Behavior and Disintegration Mechanism
In the formulation design of conventional orally disintegrating tablets (ODTs) by direct compression, disintegratablity often reduces when active pharmaceutical ingredient (API) content is high. Since API tends to block the gap between particles in tablets, which is considered to be the main water…
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Solving Compactability Issues for the Preparation of ODTs
Introduction
Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the best-in-class co-processed excipient for ODT, may work as…
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Your visit at CPhI worldwide in Milan
CPhI worldwide opens its real doors again after one year of digital trade show! This year in Milan at the Fiera Milano. Next week, from 9th to 11th November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be…
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Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and…
Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a special patient group, where an increased need in appropriate formulation development is required. To overcome these mostly swallowability linked issues, orodispersible tablets (ODTs) and orodispersible…
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Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms
Orodispersible dosage forms are attractive and innovative drug delivery systems that can fulfill individual patient needs, especially in children, elderly and among dysphagic patients. Indeed, they rapidly disperse in the mouth upon contact with the saliva without the need for water or munching.…
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The bitterness masking effect of β-cyclodextrin in the formulation of ODTs using Granfiller D
CycloLab Cyclodextrin R&D Laboratory, Ltd., Hungary and Daicel Corporation have jointly published a white paper on the bitterness masking effect of β-cyclodextrin (β-CD) in the formulation of orally disintegrating tablets (ODTs) using GRANFILLER-D.
ODTs disintegrate in the oral cavity within…
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Poster: Granfiller-D® & Hisorad® As New Co-processed Excipients For Orally Disintegrating…
Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing. This is especially relevant for special patient groups, e.g.…
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Application of mini ODTs and coin-shaped ODTs with high performance excipients for pediatric…
There is strong clinical need for pediatric formulations from healthcare professionals and caregivers since the number of available pediatric formulation is limited. Currently oral administration is the main route of administration for pediatric formulations in the market. For development of…
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Impact of co-processed excipient particles solidity and circularity on critical quality attributes…
The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability and homogeneity of powder mixtures and minitablets final…
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