ingredientpharm

In the realm of pharmaceutical formulations, the quest for efficient and reliable drug delivery systems has led to significant advancements. Among these, CELLETS®—highly spherical microcrystalline cellulose (MCC) pellets—have emerged as a pivotal component in developing multiparticulate dosage forms…
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Abstract In this study, an artificial intelligence-based machine vision system was developed for in-line particle size analysis during the pellet layering process. Drug-layered pellets were produced by coating microcrystalline cellulose cores with an ibuprofen-containing layering liquid until the…
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Abstract Topical skin products aim to address aesthetic, protective, and/or therapeutic needs through interaction with the human epidermal system. Traditionally, formulation development relies on empirical knowledge and trial-and-error experiments. In this paper, we introduced the Bayesian…
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Abstract Process Analytical Technology (PAT) plays a crucial role in the design of today’s manufacturing lines as continuous manufacturing becomes more important. Until now PAT tools to measure the ribbon solid fraction (SFribbon) in-line are not commonly used in roll compaction. The aim of this…
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The patent application US20240350420A1 focuses on pharmaceutical formulations and methods for treating conditions such as hyperhidrosis, which involves excessive sweating. The document details the development of modified-release compositions, specifically utilizing Pilocarpine HCl, a muscarinic…
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The patent WO2019123269A1, titled “Packaged modified release gamma-hydroxybutyrate formulations having improved stability“ presents innovative formulations and packaging methods designed to enhance the dissolution and chemical stability of gamma-hydroxybutyrate (GHB), a treatment for narcolepsy.…
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The patent application 20240316057 focuses on a pulsatile release formulation for caffeine, designed to control its release profile over a specific time frame. The formulation is targeted at therapeutic and non-therapeutic uses — enhancing mental alertness and addressing conditions like morning…
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The patent application titled “Modified Release Gamma-Hydroxybutyrate (GHB) Formulations Having Improved Pharmacokinetics” (US20240148685) focuses on improving the delivery of GHB, a substance used for treating sleep disorders like narcolepsy, through modified-release formulations. The goal is to…
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The patent application US20240139215A1 focuses on the development of controlled release formulations for highly lipophilic physiologically active substances, such as cannabinoids. These substances tend to have high lipid solubility (log P of 4 or more), making them difficult to deliver in a…
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The United States Patent Application US20240024263 focuses on methods of administering gamma-hydroxybutyrate (GHB) in combination with divalproex sodium (DVP), particularly for treating conditions like narcolepsy. The aim is to co-administer these drugs without altering their dosage or efficacy. The…
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