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ingredientpharm
Vitafoods Geneva 2024 – with a focus on excipients
This year Vitafoods Europe opens its doors for the last time in Geneva at Palexpo.
From 14th to 16th May you can have a face-to-face chat with visitors and exhibitors again.
Pharma Excipients gives you an overview of the excipient suppliers, their booths, main topics and products in the…
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Development of a New Bioequivalent Omeprazole Product
Abstract
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that its population has access to affordable…
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Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of…
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Gin & tonic – the first bittersweet antimalarial
During the 1700s, antimalarial properties of quinine were first unleashed. British soldiers stationed in India began drinking tonic water to prevent and combat the disease. However, quinine has a pronounced bitter taste; in the 1800s, gin was added to make the tonic more palatable. Later, lemon and…
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The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of…
The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments,…
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Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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Paediatric Solid Oral Dosage Forms for Combination Products: Improving In Vitro Swallowability of…
There is a growing interest in determining and improving the acceptability of solid oral dosage forms (SODF) in paediatric populations. Combination products can be an interesting solution to combine two active pharmaceutical ingredients. This study shows that binary mixture of paediatric SODF could…
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The impact of applying an additional polymer coating on high drug-loaded amorphous solid dispersions…
Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study was to investigate the potential surface crystallization inhibitory effect of an additional polymer coating…
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Solventless amorphization and pelletization using a high shear granulator. Part II; Preparation of…
The aim of this study was to investigate the preparation of co-amorphous mixture-layered pellets using solventless pelletization and amorphization using a high shear granulator (as suggested in the first part of this study) by high shear mixing of drug crystals and a crystalline co-former with…
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Solventless amorphization and pelletization using a high shear granulator. Part I; feasibility study…
The aim of the current study was to investigate the feasibility of solventless amorphization and pelletization using a high shear granulator, to produce amorphous drug-layered pellets by simply mixing drug crystals and inactive spheres without using solvent and heating. Indomethacin crystals were…
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