Roquette

Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was the formulation of fast-dissolving freeze-dried sublingual…
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Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and characterize pregelatinized starch-polyvinylpyrrolidone (PGS-PVP)…
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This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION An increasing number of APIs present stability challenges and corresponding tablets require to be formulated with protective…
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Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical  (PBP) Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION Tablets with stability issues often use mannitol, a stable, water-soluble excipient compatible with most drugs. Direct compression is a…
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We invite you to our next webinar: "Rethinking the development of controlled release formulations and manufacturing processes" During this webinar we will cover the key topics related to controlled release formulations in drug delivery and different manufacturing processes. We will…
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Abstract The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the…
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Abstract Nanobody molecules, derived from heavy-chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single-domain format facilitates the construction of multivalent molecules for therapeutic…
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Abstract The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer and to evaluate their release properties and physiochemical stability. The crystallization of MCP in the polymer matrix was…
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Abstract The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data matrix-generator software specifically focused on the healthcare…
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See some Frequently Asked Questions and the corresponding answers for Cyclodextrins and KLEPTOSE®: What are ß-Cyclodextrins (ß-CDs)? β-Cyclodextrins (β-CDs) are cyclic oligosaccharides with a bucket-like structure having a hydrophobic internal cavity and a hydrophilic exterior. This unique…
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