Vitamin E TPGS by PMC Isochem

D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS hase interesting properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery. There exist various TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, vaccine system adjuvant, nutritional supplement, film plasticizer and anticancer reagents.

See the product overview by PMC Isochem and have a look at the brochure:

Pharma (NF) and Food Grade

Vitamin E TPGS has been used for decades in the formulation of poorly soluble pharmaceutical drugs. Vitamin E TPGS is compatible with many oral dosage forms and stable enough to ne compatble with advanced fomulation Technologies like HME.

Application

Vit-E-TPGS has proven properties to improve bioavailability of poorly soluble drugs, vitamins, micronutrients and functional properties in advanced formulation technologies.

TPGS: Functional ingredient of Self-Emulsifying Drug Delivery System and stabilizer of amorphous solid dispersions. Plasticizer/binder for innovative technologies in the pharmaceutical industry such as hot melt extrusion. Efficient source of natural Vitamin E for both therapeutic and neutraceutical purposes.

Isodel™ TPGS: used in several marketed drug products (Functional Excipient or API)

PROPERTIES

DRUG BIOAVAILABILITY
> Solubilizer of poorly water-soluble drugs
> Enhancer of drug permeability by P-glycoprotein efflux inhibition
> Stabilizer of amorphous drug dispersions
> Co-Excipient with other Polymers​

More on Vitamin E TPGS

FUNCTIONAL INGREDIENT
> Emulsion vehicle
> Ingredient for self-emulsifying formulations
> Thermal binder in melt granulation/extrusion processing

Source: PMC Isochem brochure “isodel Vitamin E TPGS by PMC Isochem”

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See also the interesting video on Vitamin E TPGS: