A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A COMPARATIVE STUDY
Objetive: To evaluate and compared the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD) composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpirrolidone (Ludipress®), lactose (Cellactose 80®) and microcrystalline cellulose (Prosolv SMCC 90®).
Methods: All materials were tested for lubricant sensitivity, ejection force, elastic recovery, dilution potential and reworking ability. Further, compressibility and compactibility was determined using the Heckel and Leuenberger models, respectively.
EDWARD ECHEVERRI, JHON ROJAS, MAURICIO BEDOYA, A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A COMPARATIVE STUDY, VOL 8, ISSUE 4, 2016, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/8845