Advances in lipid carriers for drug delivery to the gastrointestinal tract

Lipid-based formulations have reemerged as oral drug delivery systems. Advances in the techniques to evaluate the in vivo fate of the formulations, together with an improved knowledge of the gastrointestinal-related processes/barriers to the evolving lipid-based systems, could explain, at least partially, this revival. Additionally, the use of lipid-based formulations is no longer limited to highly lipophilic drugs and has been extended to hydrophilic peptides and macromolecules. Last but not least, (targeted) nanocarriers have been developed exploiting the gut physiology towards novel targets in the field. We herein review what we believe have been the major advances in oral drug delivery via lipid-based formulations in recent years leading to their reemergence as promising drug delivery systems for future clinical application.

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Yining Xu, Cecilia Bohns Michalowski, Ana Beloqui,
Advances in lipid carriers for drug delivery to the gastrointestinal tract, Current Opinion in Colloid & Interface Science,
2020,101414,
https://doi.org/10.1016/j.cocis.2020.101414.

Keywords: lipid carrier, soral drug delivery, bioavailability, nanocapsules, SEEDS, solid lipid nanoparticles, hybrid polymer-lipid nanoparticles