Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release tablets
The coating is one of the crucial phases in the production of the tablet dosage form with extended-release profiles. Tablet coating has numerous benefits, including disguising the medicine’s odor, taste, physicochemical protection, and safeguarding the drug from the stomach environment. The aim to conduct this study was to determine the effect of varying concentrations of coating solutions on dissolution profiles. Extended-release tablet dosage form of antiepileptic drug as a prototype was developed to ensure minimize fluctuation in drug plasma levels. Tablets were prepared using two grades of HPMC methocel K100 and methocel K15 H, along with anhydrous lactose and microcrystalline cellulose followed by film coating using different concentrations of opadry white via spraying method, and results were compared with the marketed formulation.
Vaibhav Dubey, Manjit Jaiswal, Ritika Puri, Vimal Arora,
Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release tablets,
Materials Today: Proceedings, 2022, ISSN 2214-7853,
https://doi.org/10.1016/j.matpr.2022.06.140.