Moisture sealing film coating system for solid oral dosage forms

AquaPolish® MS: Moisture sealing film coating system for solid oral dosage forms.

Protecting moisture-sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements industry.

Coating the tablet core with a suitable film coating, therefore, plays an important role in achieving a sufficient moisture barrier. It improves the stability of the tablet and provides protection to prevent degradation of the active ingredients and increases shelf life. Tablet cores with highly hygroscopic active ingredients, such as extracts, or solid dosage forms marketed in countries with high humidity, must be protected from moisture effectively.

The selection of raw materials for the formulation of AquaPolish® MS is adapted to the respective active ingredient and the customer‘s requirements. The transparent, white or colored tailor-made AquaPolish® MS formulations are homogeneous dry milled and easily soluble in water. Ready-to-use in less than one hour.

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Film Properties

For the following data collection placebo tablets* were coated with three different white formulations (AquaPolish® MS, AquaPolish® based on HPMC, AquaPolish® based on PVA).

The solid concentrations and coating conditions were adjusted to the recommended values. The spray process stopped at a weight gain level of 4 % to compare all formulations under same conditions. All spray trials were performed on the laboratory drum coater BOSCH SolidLab1.

MOISTURE BARRIER

Determination of water absorption: The coated tablets (n=10) were weighed before the start of the measurement, as well as the weight per tablet per day during the time in the climatic chamber (at 40°C, 75 % RH). The measured weight difference results from the moisture absorption (shown in % in the graph).

Interest in Film Strength and Process Parameters of AquaPolish® MS?
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