Excipients for Lubrication

During tablet and capsule production, lubricants are necessary to improve powder flow and reduce friction and adherence. Lubrication is a critical step since over- or underlubrication is responsible for many production and quality issues. Therefore, lubricant type, quantity, and conditions of use are critical parameters to take into account when developing a formulation.

Advantages of Gattefossé lubricants:

Gattefossé lubricants are recommended for challenging formulations. They are also able to resolve production and quality issues due to these qualities:

chemical inertness: no reactive groups and no incompatibility with APIs or other excipients
robustness: resistant particles of homogeneous size ensure constant surface area; mixing time and speed do not change the quality of the lubrication or tablet properties
effective lubrication that preserves tablet attributes: hardness, disintegration time, and drug release

The information on the topic of lubrication excipients is taken from the chapter
“Excipients for Lubrication” from the Gattefossé website.

Range of lubricants:

Compritol^® 888 ATO for challenging pharmaceutical tablets:

highly reproducible spherical particles having a mean size of 50 µm
well-defined, highly reproducible plant-based composition
recommended for use at proportion of 1%–3% (w/w)
inertness with no reported incompatibility with APIs
lubrication unaffected by mixing time and speed
GRAS status and precedence of use with many APIs (FDA IID)

Get Compritol® 888 ATO here

Compritol^® HD 5 ATO for water dispersible tablets:

highly reproducible spherical particles having a mean size of 50 µm
well-defined, highly reproducible composition including PEG esters to increase aqueous solubility and dispersion properties
recommended for use at proportion of 1%–3% (w/w)
can also be used in orodispersible or effervescent tablets

Get Compritol® HD 5 ATO here

Precirol^® ATO 5 for powder capsule filling;