Influence of Nozzle Geometry and Scale-Up on Oil Droplet Breakup in the Atomization Step during Spray Drying of Emulsions

Spray drying of oil-in-water emulsions is a widespread encapsulation technique. The oil droplet size (ODS) significantly impacts encapsulation efficiency and other powder properties. The ODS is commonly set to a specific value during homogenization, assuming that it remains unchanged throughout the process, which is often inaccurate. This study investigated the impact of atomizer geometry and nozzle dimensions on oil droplet breakup during atomization using pressure-swirl atomizers.

Subject of the investigation were nozzles that differ in the way the liquid is set in motion, as well as different inlet port and outlet orifice dimensions. The results indicate that nozzle inlet port area may have a significant impact on oil droplet breakup, with x_90,3 values of the oil droplet size distribution decreasing from 5.29 to 2.30 µm with a decrease of the inlet area from 2.0 to 0.6 mm. Good scalability of the findings from pilot to industrial-scale was shown using larger nozzles.

A simplified theoretical model, aiming to predict the ODS as a function of calculated shear rates, showed reasonable agreement to the experimental data for different atomization pressures with coefficients of determination of up to 0.99. However, it was not able to predict the impact of different nozzle dimensions, most likely due to changes in flow characteristics. These results suggest that the stress history of the oil droplets might have a larger influence than expected. Further studies will need to consider other zones of high stress in addition to the outlet orifice.

Figure 2Features of the examined pressure-swirl nozzles. (a) The SK with the nozzle body (1), the orifice insert (2), and a slotted core with axial inlet slots (3). (b) The Mini SDX with the nozzle body (1), the outlet orifice insert (2), and a core with a single tangential inlet port (3). — **Figure 2**. Features of the examined pressure-swirl nozzles. (a) The SK with the nozzle body (1), the orifice insert (2), and a slotted core with axial inlet slots (3). (b) The Mini SDX with the nozzle body (1), the outlet orifice insert (2), and a core with a single tangential inlet port (3).

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Excipients mentioned in the study beside others: GLUCIDEX IT 12 from Roquette

Höhne, S.; Taboada, M.L.; Schröder, J.; Gomez, C.; Karbstein, H.P.; Gaukel, V. Influence of Nozzle Geometry and Scale-Up on Oil Droplet Breakup in the Atomization Step during Spray Drying of Emulsions. Fluids 2024, 9, 70. https://doi.org/10.3390/fluids9030070

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