APION® Ion Exchange Polymers

Credentials

Company has state of the art manufacturing facility certified with International EXCiPACT GMP certificate. A combine certificate of IPEC EUROPE and IPEC USA for manufacturing international standard pharma Polymers (EXCIPIENTS). EXCiPACT, Good Manufacturing Practice, ISO 9001:2008 and Halal certificate and many multinational company audit approval enabling pharmacopeial GMP International quality product manufacturing in India. Vikram Thermo (India) Limited filed US-DMF approvals across its product range.

APION® Ion exchange polymers

APION® Ion exchange polymers address two critical needs in modern pharmaceutical formulations: taste masking of bitter APIs and rapid disintegration. With growing demand for patient-friendly dosage forms, especially in pediatric and geriatric segments, taste acceptability is as important as therapeutic efficacy. APION efficiently bind bitter-tasting APIs, significantly reducing perception on the palate and ensuring better compliance without altering the drug´s pharmacological profile.

Beyond palatability, APION® promote faster disintegration and dissolution, enabling quicker onset of action and enhanced bioavailability. Their versatility makes them ideal for innovative oral dosage forms, including orally disintegrating tablets (ODTs), chewables, suspension and dry syrups.

By integrating APION®, manufacturers gain a competitive advantage, producing formulations that combine efficancy with patient convenience, With proven reliability, consistent performance, and multifunctional benefits, APION® is shaping the future of excipient technologies in the pharmaceutical industry.

“Advancing patient centric formulations.”

Mission

Our mission is to be a global leader in excipients, driven by advancement, reliability & expertise. Delivering international quality, cost-effective solutions every time.

Vision

To create excipients that improve lives, safeguard the planet, & leave a lasting impact on communities & industries worldwide

APION®T Series Ion exchange polymers for taste masking

Ion exchange polymers replace their own ions with desirable charged ions in solution. When a charged API interacts with the polymer, ionic bonding forms a resinate, its strength influenced by factors like particle size, crosslinking, pH, and pKa values of both polymers and API.

Finer polymers enhance surface area and diffusion, while higher crosslinking may limit drug loading. Establishing the optimal binding ratio and process parameters ensurers efficient taste masking and reliable, patient-friendly formulations.

Advantages of ion exchange polymers for taste masking

Effectice bitterness suppression: Stable drug resinate complexes prevent drug release in saliva, eliminating bitter after-taste.

Immediate release: Complex dissociates quickly in stomach fluid for immediate therapeutic action.

Simple & cost-effective: No additional coating or complex manufacturing steps required.

Versatility: Compatible with a wide range of cationic and anionic APIs.

Enhanced stability: Protects APIs against moisture, heat, and light.

Formulation flexibility: Easily incorporated into tablets, capsules, suspensiondry syrups, orally disintegrating dosage forms.

Improved patient compliance: Enhances palatability, especially for pediatric and geriatric patients.

APION® T SERIES

Excipients in the shop: APION® T51, APION® TA 42, APION® TC 42, APION® DT 44

APION® D Series Rapid tablet disintegration

APION® D Series is a highly pure, weak acid cation exchange polymers supplied as a fine, free flowing dry powder in the potassium form. It acts as a super-fast pharmaceutical disintegrant, delivering rapid tablet breakup through swelling when exposed to water or gastrointestinal fluids. Its unique mechanism creates a strong bursting effect for superior disintegration performance

Unlike gums that may dissolve or form sticky masses upon hydration, APION® D Series swells uniformly, promoting even disintegration without stichiness. It performs effectively in both hydrophobic and hydrophilic formulations, while maintaining excellent compressibility during tablet manufacturing. Its outstanding efficiency makes it a preferred choice over conventional disintegrants.

Swelling index

Swelling is a primary mechanism for tablet disintegration. As a disintegrant absorbs fluid, it expands, generating internal pressure that forces tablet particles apart, leading to rapid breakup.

The effectiveness of a disintegrant is measured by its swelling volume. An ideal disintegrant exhibits high swelling without affecting the tablet´s other physiochemical properties. Swelling volume is determined by immersing the dry polymer in a suitable solvent for a set time and measuring the increase in volume once full swelling occurs.

See the full leaflet on APION® Ion Exchange Polymers here:

(click the picture to download the leaflet)

Source: Vikram Thermo brochure APION® Ion Exchange Polymers

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