Strengthening the sustained release efficiency of a formulation by employing Kollicoat® SR 30 as binder-liquid in wet granulation

Poly(vinyl acetate) [PVAc] – based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added for adjusting drug release. The combination of both excellent solubility and high content of the active ingredient might lead to formulations with high dissolution rates even with PVAc.

PVAc is available in two different forms: as constituent in the direct compression (DC) vehicle Kollidon® SR and as aqueous dispersion Kollicoat® SR 30 D.

This work was set to investigate how the application of an aqueous dispersion during a high shear granulation process influences the properties of the resulting agglomerates and tablets as well as the dissolution characteristics of the API.

PDF DOWNLOAD: Kollicoat® SR 30 as binder-liquid

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