MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations

A 100% MCC sphere, Celphere™ has high sphericity and narrow particle size distribution. Also, Celphere™ is less damaged during film coating process because of its high mechanical strength. With regard to comparison with sugar spheres, Celphere™ can prevent agglomeration during film coating process because of its moderate water absorption capacity without dissolving. In addition, film coated granules with Celphere™ are more robust against external shear stress such as the gastrointestinal tract because of its insolubility. These functions and features of Celphere™ facilitates precise dissolution profiles of controlled release formulations.

We offer 5 grades of Celphere™ with different particle size ranges

Grade	Particle size range (μm)	Sphericity	Bulk density (g/ｍL)	Water absorption (%)
CP-102	106-212	1.2	0.83	100
CP-203	150-300	1.1	0.87	100
CP-305	300-500	1.1	0.97	110
CP-507	500-710	1.2	0.97	70
CP-708	710-850	1.2	0.93	65

All values presented here are solely for the purpose of basic reference and should not be regarded as specifications

Source: Asahi Kasei

Tags: excipients formulation

MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations

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