Solid microneedle assisted transepidermal delivery of iloperidone loaded film: Characterization and Skin deposition studies

Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on transepidermal delivery of Iloperiodone across the neonatal porcine skin ex-vivo. In this study, the response surface technique with 3² factorial design is used for Iloperidone (ILO) transdermal films optimization. ATR-FTIR, DSC, tensile strength, and water vapor barrier tests were used to characterize the transdermal films. Further epidermal water loss, dissolution, ex-vivo permeation, and Skin deposition studies were carried out for solid microneedle.

Highlights

ILO complex loaded PVA transdermal film was prepared by solvent casting method and optimised by 3² factorial design.

Dermaroller was used for micropore formation for effective delivery of ILO transepidermally.

Microneedle assisted transdermal film retained a significant amount of drug in the skin over 24h.

Poke and patch approach facilites the practical applications of microneedle-based drug delivery technology.

The optimized transdermal film increased the dissolution profile of the drug with high folding endurance and showed stability for six months. Higuchi kinetic model is considered to be the best fit model. The mean flux of microneedle-treated transdermal film of ILO, determined using a developed HPLC technique, was 21.28 ± 0.15 μg/cm²/h. Flux was observed to be substantially greater in microneedle-treated skin than in passive skin. The current study emphasizes that the poke-and-patch method could be used to deliver an antipsychotic medication transepidermally.

Rupali S. Bhadale, Vaishali Y. Londhe, Solid microneedle assisted transepidermal delivery of iloperidone loaded film: Characterization and Skin deposition studies, Journal of Drug Delivery Science and Technology, 2022, 104028, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2022.104028.