Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and technologies

Microwave irradiation technology has a lot of applications in the field of food processing, organic synthesis, pharmaceuticals, and biomedical therapy. The basic mechanisms observed in microwave-assisted syntheses are dipolar polarization and conduction. Of late, it has gained tremendous attention in the synthesis of drug delivery systems for enhanced solubility, dissolution rate, and biopharmaceutical attributes. Considering the myriads of advantages over conventional heating such as high percentage yield, lesser reaction time, deep penetration of heat, and improved product quality; microwave-assisted technology holds potential in the development of nano- and microparticle-based drug delivery systems with improved physicochemical characteristics and thereby, bioavailability. In this review, we have discussed the formulation of drug delivery systems which includes lipidic, polymeric, metallic, and micellar nanoparticles. We have also summarized solid dispersion, dendrimers, and carbon nanotubes in this manuscript. However, it is possible to expedite the extraction process, save expenses, and increase the effectiveness, reliability, and simplicity of responses. Therefore, microwave technology provides a new avenue for the development of drug delivery systems in various biomedical applications.

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Shachi Virlley, Shipra Shukla, Sanchit Arora, Deeksha Shukla, Deepak Nagdiya, Tanya Bajaj, Sima Kujur, Garima Malik, Arun Kumar, Jasvinder Singh Bhatti, Arti Singh, Charan Singh, Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and technologies, Journal of Drug Delivery Science and Technology, 2023, 104842, ISSN 1773-2247,
https://doi.org/10.1016/j.jddst.2023.104842.