Solid lipid nanoparticles: a promising tool for insulin delivery
Introduction
Insulin plays a critical role in metabolism modulation including carbohydrate, lipid, and protein metabolism. There is room to improve insulin delivery but optimizing the best carrier remains challenging. Traditional and conventional approaches for insulin delivery do not emulate the normal fate of insulin release in the body. Despite extensive research attempts to overcome this and other challenges, the goal of achieving optimal insulin delivery that emulates the natural system remains unresolved.
Article highlights
- Insulin plays a critical role in metabolism modulation including carbohydrate, lipid and protein metabolism.
- Goal of achieving optimal insulin delivery that emulates the natural system remains unresolved yet.
- An overview of the suitability and application of Solid Lipid Nanoparticles (SLNs) for insulin delivery.
- A special emphasis is placed on the biopharmaceutical aspects of insulin loaded SLNs.
- SLNs have proven to be safe and versatile drug delivery systems suitable for insulin delivery.
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Areas covered
Solid Lipid Nanoparticles (SLNs) may provide a solution, because they are nontoxic, biocompatible, and straightforward to formulate thus providing a promising platform for achieving targeted and controlled delivery of various therapeutic agents. This review aims to provide an overview on the suitability and application of SLNs for insulin delivery. A special emphasis is placed on the biopharmaceutical aspects of insulin loaded SLNs which have not been explored in detail to date.
Fatemeh Mohammadpour, Hossein Kamali, Leila Gholami, Alice P. McCloskey, Prashant Kesharwani, Amirhossein Sahebkar, Solid lipid nanoparticles: a promising tool for insulin delivery, Received 18 May 2022, Accepted 17 Oct 2022, Accepted author version posted online: 26 Oct 2022, Published online: 02 Nov 2022, https://doi.org/10.1080/17425247.2022.2138328