The Effect of Particle Size on The Sublimation of Butylhydroxytoluene in Tablets

The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients community.

As many scientists send us their posters we will show several posters of the PBP Poster Session stepwise over the next weeks.

The next poster in our series was presented by Milan Decorte from Ghent University:
(click on the poster to enlarge it)

Download the research poster as PDF: The Effect of Particle Size on The Sublimation of Butylhydroxytoluene in Tablets

Introduction

• An increase in the number of oxidation-sensitive APIs in recent years can require the implementation of antioxidants in oral solid dosage forms.
• The antioxidant butylhydroxytoluene (BHT) sublimates at higher temperatures, which could cause problems during processing.

Objectives

• Determination of the extent of BHT sublimation in tablets.
• Investigating the influence of particle size of BHT on the sublimation behaviour.

Materials and Methods

• MEDELPHARM STYL’One Evo
  -> Uniaxial confined compression at 25 kN in a 11.28 mm die
• Formulation: 1% w/w BHT – 0.5% w/w MgSt – 98.5% w/w MCC PH-102

Authors

Milan Decorte
M. Decorte 1, B. Van Hove 2, F. Preda 2, E. Verheyen 2, N. Moazami Goudarzi 3, M. Boone 3, C. Vervaet 1, V. Vanhoorne 1
1 Ghent University, Laboratory of Pharmaceutical Technology, Ottergemsesteenweg 460, 9000 Ghent, Belgium
2 Janssen, Pharmaceutical companies of Johnson & Johnson, division Chemical and Pharmaceutical Development and Supply, Turnhoutsesteenweg 30, 2340 Beerse, Belgium
3 Ghent University, Centre for X-Ray Tomography – UGCT, Proeftuinstraat 86, 9000 Ghent, Belgium