Polymers for Pharmaceutical and Biomedical Applications – New Interesting Book
See the new book, edited by Vandana Patravale, John Disouza and Aliasgar Shahiwala.
Key Features
- Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers
- Guides the reader towards successful selection of polymer systems for specific target applications
- Addresses key challenges in this field that are supported by case studies and regulatory information
Description
Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are highlighted, with chapters explaining the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, and more. Throughout the book, the aim is to provide accessible, step-by-step coverage supported by diagrams and case studies. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting.
Chapter 1
Pharmaceutical and biomedical polymers: Basics, modifications, and applications
At present, polymers are deemed indispensable in many aspects of human life including health and wellness. Polymers are broadly categorized as natural, semi-synthetic, and synthetic polymers. Natural polymers have been used since ancient times for the betterment of human health, whereas the pharmaceutical and biomedical applications of semi-synthetic and synthetic polymers have been on the rise since the 1930s. In this book chapter, we provide essential information about natural, semi-synthetic, and synthetic polymers of pharmaceutical and biomedical importance. For every polymer type or class, we provide a general structure and describe polymer synthesis methods, key physicochemical properties, and important pharmaceutical and biomedical applications including commercially available products.
Joseph S. Adams, Yogesh Sutar, Sagar Dhoble, Chiranjit Maiti, Sonali Nitin Hanjankar, Rajeswari Das, Vandana Patravale, Abhijit A. Date, Chapter 1 – Pharmaceutical and biomedical polymers: Basics, modifications, and applications, Editor(s): Vandana Patravale, John Disouza, Aliasgar Shahiwala, Polymers for Pharmaceutical and Biomedical Applications, Elsevier, 2024, Pages 1-86, ISBN 9780323954969, https://doi.org/10.1016/B978-0-323-95496-9.00001-6.
Chapter 5
Pharmaceutical polymers in conventional dosage forms
Polymers are very useful excipients in the development of solid, liquid, and semi-solid pharmaceutical dosage forms. For this purpose, it is important to select a polymer based on its overall compatibility with the drug candidate to be incorporated in the formulation. In addition, polymers to be used in pharmaceutical dosage forms should be biocompatible, biodegradable, and improve the stability of formulations. They should facilitate the encapsulation of both hydrophilic and lipophilic drugs. In selecting a biopolymer for drug formulation, the properties of the polymer including its crystallinity, molecular weight, interaction with drug molecules, and biodegradation pathway, must be considered. Several polymers classified as natural, semi-synthetic, or synthetic are available for dosage form development. Advances in polymer chemistry and the possibility of surface modification have expanded the scope of application of polymers in dosage form design. Beyond drug formulations, polymers have also found application in the fabrication of membranes and barriers used for testing the efficacy of dosage forms. These applications of polymers and new frontiers established underline the great potentials of polymers in dosage form design.
Chukwuebuka Emmanuel Umeyor, Sarika Anand Jadhav, Sonali Nitin Hanjankar, Kartik Ravikant Nimkar, Vandana Patravale, Chapter 5 – Pharmaceutical polymers in conventional dosage forms, Editor(s): Vandana Patravale, John Disouza, Aliasgar Shahiwala, Polymers for Pharmaceutical and Biomedical Applications, Elsevier, 2024, Pages 153-198, ISBN 9780323954969, https://doi.org/10.1016/B978-0-323-95496-9.00005-3.
Chapter 6
Pharmaceutical polymers for modified drug delivery and controlled release
Modified release systems provide spatial and temporal control over the release of drugs and therapeutic agents from dosage forms. These systems have gained great interest recently due to various advantages including increased control over the blood plasma profile, precision medicine by virtue of drug targeting, reduced toxicity and side-effects and improved patient compliance. A number of biocompatible polymers and biomaterials having versatile properties have been explored for modifying drug release. Such polymers are most commonly used in tablets and other oral dosage forms to provide a sustained or controlled release profile or to target the drug to the stomach (gastroretentive drug delivery systems), small intestine (enteric coated dosage forms) or large intestine (colon-targeted drug delivery systems). Further, a number of mucoadhesive polymers have been used widely to provide modifed drug release in various mucosae of the body including buccal, sublingual, ocular, nasal, vaginal and rectal. In situ gelling polymers which gel in response to various stimuli such as temperature, pH or ions, have also recently gained popularity for ocular and direct nose-to-brain drug delivery, and for depot/implant-forming injections. This chapter explains in detail, the use of pharmaceutical polymers for each of these applications, giving examples of marketed formulations as well as providing an updated review of the scientific literature.
Dhruv Sanjanwala, Namrashee V. Mehta, Vandana Patravale, Chapter 6 – Pharmaceutical polymers for modified drug delivery and controlled release, Editor(s): Vandana Patravale, John Disouza, Aliasgar Shahiwala, Polymers for Pharmaceutical and Biomedical Applications, Elsevier, 2024, Pages 199-260, ISBN 9780323954969, https://doi.org/10.1016/B978-0-323-95496-9.00006-5.
Chapter 11
Regulation of pharmaceutical polymers
Excipients play a critical role in successful pharmaceutical product development, to the extent it is said that “when you add an excipient to an API you get a medicine.” Polymer is one such excipient whose utilization in finished product or formulation development has increased to a great extent due to the varied unique function, properties, and attributes offered by them.
Since polymers are a part of the formulation and are covered under excipients, they need to be manufactured and tested as per the regulatory guidelines. This chapter provides an insight into the regulatory aspects of polymers in pharmaceutical and biomedical applications; used as excipients, for packaging, and in medical devices.
Parizad Elchidana,
Chapter 11 – Regulation of pharmaceutical polymers, Editor(s): Vandana Patravale, John Disouza, Aliasgar Shahiwala,
Polymers for Pharmaceutical and Biomedical Applications, Elsevier, 2024, Pages 425-450, ISBN 9780323954969, https://doi.org/10.1016/B978-0-323-95496-9.00011-9.
See the full book here
Vandana Patravale, John Disouza and Aliasgar Shahiwala, Polymers for Pharmaceutical and Biomedical Applications Fundamentals, Selection, and Preparation, Book • 2024, https://www.sciencedirect.com/book/9780323954969/polymers-for-pharmaceutical-and-biomedical-applications#book-info, Front Matter,Pages i-iii,ISBN 9780323954969, https://doi.org/10.1016/B978-0-323-95496-9.09991-9.