Oral Solids – Practical Pharmaceutics Part 2

An International Guideline for the Preparation, Care and Use of Medicinal Products

See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:

Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality control, logistics, dispensing and use of medicines. It features chapters written by experienced pharmacists and scientists working in hospitals, academia and industry throughout Europe, including practical examples as well as information on current GMP and GMP-based guidelines and EU-legislation. In this second edition all chapters have been updated with numerous new as well as didactically revised illustrations and tables. A completely new chapter about therapeutic proteins and Advanced Therapy Medicinal Products was added.

From prescription to production, from usage instructions to procurement and the impact of medicines on the environment, the book provides step-by-step coverage that will help a wide range of readers, students as well as professionals. It offers product knowledge for all pharmacists working directly with patients and it will enable them to make the required medicine available, to store medicines properly, to adapt medicines if necessary and to dispense medicines with the appropriate information for patients as well as caregivers about product care and how to maintain the quality of the product. The basic knowledge presented in the book will also be valuable for industrial pharmacists to remind and focus them on the application of the medicines manufactured.

The basic and practical knowledge on the design, preparation and quality management of medicines can directly be applied by the pharmacists whose main duty is production in community and hospital pharmacies and in industry. Undergraduate as well as graduate pharmacy students will find knowledge presented in a coherent way and fully supported with relevant examples.

Practical Pharmaceutics has become a reliable and recognised source for the acquisition of pharmaceutical-technological knowledge. The book is used in the curriculum of a number of international universities and schools of Pharmacy.

Chapter 12

Oral Solids

This chapter provides the pharmaceutical basis of common solid dosage forms and discusses biopharmaceutical aspects related to their formulation. There is a need for customised capsules and powders, usually when the required dose is not available as a licensed product and this dose cannot be obtained by splitting of tablets. Swallowing problems may be another reason. The aspects related to the excipients to be used and factors affecting the processing of materials, and thus the performance of the final product, are discussed in this chapter. The design of formulations and quality control of powders and capsules are presented in detail.

The pharmacist can prepare capsules or powders from the pure active substance or, when this is not available, from pulverised tablets and the contents of higher dosed capsules. Non-coated tablets can usually be pulverised. Modified-release tablets or enteric-coated tablets can be processed in only a limited number of cases. Critical steps in the preparation of solid oral dosage forms are discussed: the preparation of a homogeneous powder mixture and evenly dividing the powder mixture over the dosage units.

Finally, this chapter discusses recent developments, such as 3D printing of oral solids and the production of orodispersible films. These techniques can be a useful addition to the pharmacist’s toolbox, as they do not have the disadvantages of traditional compounding methods.

See the chapter

van Basten, B. (2023). Oral Solids. In: Le Brun, P., Crauste-Manciet, S., Krämer, I., Smith, J., Woerdenbag, H. (eds) Practical Pharmaceutics. Springer, Cham. https://doi.org/10.1007/978-3-031-20298-8_12

See the full book here

Practical Pharmaceutics, Springer International Publishing, Le Brun, Paul, Crauste-Manciet, Sylvie, Krämer, Irene, Smith, Julian, Woerdenbag, Herman, April 2023, DOI: 10.1007/978-3-031-20298-8, ISBN: 978-3-03-120297-1, 978-3-03-120298-8

There will be to addtional articles here soon with the remaining book chapter contents:

• See Part 1 – Raw Materials
• See Part 3 – Rectal and Vaginal