Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers

Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.

Highlights

Electrospinning process was employed to produce core-shell PVA/PCL nanofibers.

Core-shell PVA/PCL nanofibers incorporating phenytoin and Ag-chitosan nanoparticles

The incorporated drugs improved the thermal and mechanical properties of the fibers.

Phenytoin released in a sustained manner by a Fickian diffusion (n value ˂ 0.5)

The proposed core-shell nanofibers offered promising cytobiocompatible platforms.

The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.

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Article information: Mohamed Ahmed Mohamady Hussein, Ece Guler, Erkan Rayaman, Muhammet Emin Cam, Ali Sahin, Mariusz Grinholc, Demet Sezgin Mansuroglu, Yesim Müge Sahin, Oguzhan Gunduz, Mamoun Muhammed, Ibrahim M. El-Sherbiny, Mosaad Megahed, Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers, Carbohydrate Polymers, Volume 270, 2021. https://doi.org/10.1016/j.carbpol.2021.118373.