SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from SEPPIC

The value proposition for formulation scientists is: 

• A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
• Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
• A texture optimal for patient compliance (even with high % of solvents) : fresh touch, non-greasy, emollient
• Easy process with Simaline L80 and its liquid form, the possibility to make the emulsion even in a cold process with low shear

Get SIMALINE™ L80 here

An innovative dosage form with strong technical performances

A Geltrap™ is the result of the enveloping of a gel-textured aqueous phase in a lipidic film, stabilized by a polymeric W/O emulsifier.

Geltrap™ dosage form:

• A combination of IID-listed & Ph.Eur. excipients
• A vehicle for polar solvents, even at high concentrations
• Unique texture, for an optimal patient compliance
• Added benefits
  • Moisturizing
  • Emollient
  • Water resistance
• Easy and versatile formulation process

Internal Aqueous phase > 80%

Gel = Water – Polar solvents – Sepineo™ Polymer

Sepineo™ P 600 (liquid) – IID registered – DMF
or Sepineo ™ D.E.R.M (powder) – DMF
or Sepineo™ PHD 100 (powder) – DMF (ongoing)

External fatty phase 5 – 20%
Oils – W/O surfactants

Simaline™ L80: 

PEG-30 Dipolyhydroxystearate (polymeric surfactant) – Ph.Eur.
Sorbitan Oleate – Ph.Eur., USP-NF

A robust polymeric surfactant, opening the possibility of emulsification in all kind of settings

• From room-temperature to hot process
• From low shear to high shear

Get SIMALINE™ L80 here

Improved aesthetics and sensorial profile, even in solvent-rich formulations

Building a dosage form to solubilize and deliver a specific API into the skin can lead you to use excipients negatively impacting the touch of your final product. With the Geltrap™ technology, you can formulate these same excipients and still ensure a positive patient experience.

Added benefits for medicated skincare

Superior moisturizing properties

• A Geltrap with only 20% Glycerin achieve significantly better moisturizing results compared to a benchmark with 40% Glycerin

Emollient vehicle

• A Geltrap with 10% of oil shows the same non-drying properties as an O/W or W/O emulsion with 20% oil

Water-resistance

• Useful property for vaginal-rectal applications, to prevent the early wash-out of the drug by body fluids

Manufacturing

Watch the full manufacturing process here in the video:

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Get SIMALINE™ L80 here