SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from SEPPIC
The value proposition for formulation scientists is:
- A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
- Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
- A texture optimal for patient compliance (even with high % of solvents) : fresh touch, non-greasy, emollient
- Easy process with Simaline L80 and its liquid form, the possibility to make the emulsion even in a cold process with low shear
![SIMALINE L80 properties]()
An innovative dosage form with strong technical performances
A Geltrap™ is the result of the enveloping of a gel-textured aqueous phase in a lipidic film, stabilized by a polymeric W/O emulsifier.
Geltrap™ dosage form:
- A combination of IID-listed & Ph.Eur. excipients
- A vehicle for polar solvents, even at high concentrations
- Unique texture, for an optimal patient compliance
- Added benefits
- Moisturizing
- Emollient
- Water resistance
- Easy and versatile formulation process
Internal Aqueous phase > 80%
Gel = Water – Polar solvents – Sepineo™ Polymer
Sepineo™ P 600 (liquid) – IID registered – DMF
or Sepineo ™ D.E.R.M (powder) – DMF
or Sepineo™ PHD 100 (powder) – DMF (ongoing)
External fatty phase 5 – 20%
Oils – W/O surfactants
Simaline™ L80:
PEG-30 Dipolyhydroxystearate (polymeric surfactant) – Ph.Eur.
Sorbitan Oleate – Ph.Eur., USP-NF
A robust polymeric surfactant, opening the possibility of emulsification in all kind of settings
- From room-temperature to hot process
- From low shear to high shear
Improved aesthetics and sensorial profile, even in solvent-rich formulations
Building a dosage form to solubilize and deliver a specific API into the skin can lead you to use excipients negatively impacting the touch of your final product. With the Geltrap™ technology, you can formulate these same excipients and still ensure a positive patient experience.
Added benefits for medicated skincare
Superior moisturizing properties
- A Geltrap with only 20% Glycerin achieve significantly better moisturizing results compared to a benchmark with 40% Glycerin
Emollient vehicle
- A Geltrap with 10% of oil shows the same non-drying properties as an O/W or W/O emulsion with 20% oil
Water-resistance
- Useful property for vaginal-rectal applications, to prevent the early wash-out of the drug by body fluids
Manufacturing
Watch the full manufacturing process here in the video: