Solid State Compatibility Studies of Miconazole Using Thermal and Spectroscopic Methods - Article

06. August 2015

Drug excipient physicochemical characterization is a systematic approach towards design of therapeutically active and stable dosage forms. The rapid advancements in novel drug delivery systems have led to an interest by formulation scientists in the role and functionality of the excipients. Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), and Powder X-ray diffractometry (XRD) analytical techniques of high resolution were used to get an insight on solid state properties of the drug and evaluate drug-excipient compatibility. Preformulation studies which were performed using thermal and spectroscopic techniques implied compatibility of phospholipon 90, cholesterol and carbapol 934 excipients with the drug miconazole nitrate.

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Materials and Methods

The drug miconazole nitrate was obtained as a gift sample from GlaxoSmithKline Pharma Ltd., Mumbai. Cholesterol (Lobachemie), Polymer-Carbapol 934 (HPL Chemicals) were used in the study. Phospholipon 90 (phosphatidylcholine) was obtained as a kind gift from Lipoid GmbH, Ludwigshafen, Germany. All the chemicals and solvents used in the study were of analytical grade.

Alka Gupta, Hemanta Kumar Kar,Solid State Compatibility Studies of Miconazole Using Thermal and Spectroscopic Methods, Advances in Analytical Chemistry, p-ISSN: 2163-2839 e-ISSN: 2163-2847, 2015; 5(3): 51-55, doi:10.5923/j.aac.20150503.01