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Study of different super-disintegrants and their use as a magic ingredient for different immediaterelease tablets
Study of different super-disintegrants and their use as a magic ingredient for different immediaterelease tablets
The time taken by the tablet to break down into fragments or granules is called disintegration. The time it takes for a batch of tablets to dissolve into particles under certain circumstances is called a disintegration test. It essentially entails an aqueous liquid penetrating the tablet, disrupting internal bonds, and the tablet breaking down as a result. A gadget defined in the USP/NF is used to determine how long it requires a tablet to dissolve. The powder compact’s disintegration and dissolution behavior have the greatest impact on a drug’s performance. For immediate-release dose formulations, the breakdown process is very important.
Table-1: List of different Disintegrating agents and their concentrations
| Sl No | Disintegrant | Proprietary name | Concentration used (%) |
|---|---|---|---|
| 1 | Alginic acid | Norgine | 2-10 |
| 2 | Carboxymethylcellulose sodium | 1-5 | |
| 3 | Cellulose, microcrystalline | Avicel, Emcocel, Vivacel | Upto 10 |
| 4 | Starch, pregelatinized | Lycatab, Pharma-Gel, Pre-Jel, Sepistab | 5-10 |
| 5 | Starch | 2-10 | |
| 6 | Sodium starch glycolate | Explotab, Primojel | 2-8 |
| 7 | Croscarmellose sodium | Ac-di-Sol, Solutab | 0.5-5 |
| 8 | Dioctyl sodium sulfosuccinate | Colace | 0.5-1 |
| 9 | Crosprovidone | Kollidon CL, Polyplasdone XL | 2-5 |
| 10 | Guar gum | 2-8 | |
| 11 | Sodium alginate | Manucol | 2.5-10 |
| 12 | Polacrilin potassium | Amberlite | 2-10 |
Download the full study as PDF here Study of different super-disintegrants and their use as a magic ingredient for different immediaterelease tablets
Amlan Bishal, Kazi Asraf Ali, Bratati Bandyopadhyay, Reechik Bandyopadhyay, Biplab Debnath. Study of different super-disintegrants and their use as a magic ingredient for different immediate release tablets, Journal of Pharmaceutical Negative Results, Volume 13, Special Issue 5, 2022
DOI: 10.47750/pnr.2022.13.S05.194
