Study of different super-disintegrants and their use as a magic ingredient for different immediaterelease tablets

The time taken by the tablet to break down into fragments or granules is called disintegration. The time it takes for a batch of tablets to dissolve into particles under certain circumstances is called a disintegration test. It essentially entails an aqueous liquid penetrating the tablet, disrupting internal bonds, and the tablet breaking down as a result. A gadget defined in the USP/NF is used to determine how long it requires a tablet to dissolve. The powder compact’s disintegration and dissolution behavior have the greatest impact on a drug’s performance. For immediate-release dose formulations, the breakdown process is very important.

Table-1: List of different Disintegrating agents and their concentrations

Sl No	Disintegrant	Proprietary name	Concentration used (%)
1	Alginic acid	Norgine	2-10
2	Carboxymethylcellulose sodium		1-5
3	Cellulose, microcrystalline	Avicel, Emcocel, Vivacel	Upto 10
4	Starch, pregelatinized	Lycatab, Pharma-Gel, Pre-Jel, Sepistab	5-10
5	Starch		2-10
6	Sodium starch glycolate	Explotab, Primojel	2-8
7	Croscarmellose sodium	Ac-di-Sol, Solutab	0.5-5
8	Dioctyl sodium sulfosuccinate	Colace	0.5-1
9	Crosprovidone	Kollidon CL, Polyplasdone XL	2-5
10	Guar gum		2-8
11	Sodium alginate	Manucol	2.5-10
12	Polacrilin potassium	Amberlite	2-10

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Amlan Bishal, Kazi Asraf Ali, Bratati Bandyopadhyay, Reechik Bandyopadhyay, Biplab Debnath. Study of different super-disintegrants and their use as a magic ingredient for different immediate release tablets, Journal of Pharmaceutical Negative Results, Volume 13, Special Issue 5, 2022
DOI: 10.47750/pnr.2022.13.S05.194