Preparation of sustained-release tablets using a solventless-mixing tablet coating technique: Particle design of dry ammonioalkyl methacrylate copolymer latex with high coating performance using sodium lauryl sulfate

The aim of this study was to produce sustained-release tablets by V-shaped blending of polymer and tablets without using solvents or heating, and we investigated the design of polymer particles with high coating performance by modifying the structure of the particles using sodium lauryl sulfate. Dry-latex particles of ammonioalkyl methacrylate copolymer were prepared by adding the surfactant into aqueous latex, followed by freeze drying. The resulting dry latex was mixed with tablets (1:10) using a blender and the resulting coated tablets were characterized. Tablet coating by the dry latex was promoted as the weight ratio of surfactant to polymer increased. At a surfactant ratio of 5%, deposition of the dry latex was most effective and the resulting coated tablets (annealed at 60 °C/75%RH for 6 h) exhibited sustained-release characteristics over a period of 2 h. The addition of SLS prevented coagulation of colloidal polymer in the freeze drying, resulting in a loose-structured dry latex. This latex was easily pulverized by V-shaped blending with tablets and the resulting fine particles with high adhesiveness were deposited on the tablets. However, at a surfactant ratio of 10%, the coating of dry latex decreased due to reduced adhesiveness.

Materials

Acetaminophen (AAP) (Tokyo Chemical Industry Co. Ltd., Tokyo, Japan) was used as the model drug. Lactose monohydrate granules (LAC) (SuperTab30GR, DFE Pharma, Goch, Germany) and microcrystalline cellulose granules (MCC) (CEOLUS UF-702, Asahi Kasei Corporation, Tokyo, Japan) were used as excipients for direct tableting and magnesium stearate (Mg-St) (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) was used as a lubricant. The aqueous latex (AL) of ammonioalkyl methacrylate copolymer type

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Keita Kondo, Sayaka Ohta, Toshiyuki Niwa, Preparation of sustained-release tablets using a solventless-mixing tablet coating technique: Particle design of dry ammonioalkyl methacrylate copolymer latex with high coating performance using sodium lauryl sulfate, European Journal of Pharmaceutics and Biopharmaceutics, 2023, ISSN 0939-6411,
https://doi.org/10.1016/j.ejpb.2023.05.001.