Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded linoleic acid transferosomes on acne

Natural medicines are promising platforms for competent topical treatment modalities benefiting the cosmetic implementation and proffering solutions to the current remedies. Therefore, the objective of this study was to formulate syringic acid (SA), well-known for its multilateral anti-inflammatory, antimicrobial and antioxidant potentials, in newly developed linoleic acid (LA) transferosomes as an anti-acne nano-form remedy. Herein, LA was incorporated in transferosomes owing to its antimicrobial effect and dermal penetrability.

Comprehensive appraisal through physicochemical, antioxidant and dermal deposition investigations was conducted. Clinical assessment was also performed in acne patients and compared with the marketed product (Adapalene® gel). The relevant investigations of the optimum formula indicated stable vesicles with a small-sized diameter (147.46 nm), surface charge (-26.86 mV), spherical architecture, reasonable entrapment (76.63%), considerable antioxidant activity (IC50 = 11.1 µg/mL) and remarkable skin deposition (78.72%).

More importantly, LA based transferosomes enclosing SA exhibited inflammation lessening in acne sufferers as manifested by greater reduction in the total count of the acne lesions reaching 79.5% in contrast to Adapalene® gel with only 18.7% reduction in acne lesions. Interestingly, no irritation and erythema were reported for the proposed transferosomes. Inclusively, the cosmetic formulation practice could reap benefits of the development of such vesicles.

Materials

Syringic acid (SA), linoleic acid (LA), tween 80, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and diphenyl-1-picrylhydrazyl (DPPH) were procured from Sigma-Aldrich, USA. Epikuron® TM 200 (phosphatidylcholine “PC”) was generously supplied by Cargill, Minneapolis, MN. Sodium chloride, disodium hydrogen phosphate, potassium dihydrogen phosphate, and ethanol were provided from El-Nasr Pharmaceutical Co., Egypt. Adapalene® gel was purchased from Borg company, Egypt.

Read more

Hend Abd-allah, Maha H Ragaie, Enas Elmowafy, Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded linoleic acid transferosomes on acne, International Journal of Pharmaceutics, Volume 639, 2023, 122940, ISSN 0378-5173,
https://doi.org/10.1016/j.ijpharm.2023.122940.