Taste Masking of Drug Layered Pellets with the Kollicoat® Smartseal 100P
Taste-masking has proven to be a useful technique to improve patient compliance of oral dosages having bitter actives, especially for pediatric and geriatric products. Kollicoat® Smartseal 100P, a spray dried powder of methyl methacrylate-diethylaminoethyl methacrylate copolymer is an excellent coating polymer for taste masking as it is insoluble in saliva (pH 6.8-7.2) and dissolves quickly in the stomach (pH < 5.5).
Highly soluble drugs when being coated can generate high osmotic pressure, resulting in a high concentration gradient across the coating layer and accelerating the drug release. This causes challenges for taste masking of water-soluble actives. In this study, the purpose is to evaluate the taste masking effect of Kollicoat® Smartseal 100P by using Diphenhydramine HCl (DPH), a highly water-soluble drug with strong bitter taste the model drug.
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