Tefose® 63: Oil-in-water emulsifier for topical dosage forms

A multi-component system

Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base (Figure1, click to enlarge).

Melt characteristics

Tefose® 63 has a wide melting range (Figure 2), from about 20 to 60°C, which implies:

• A temperature of 70-80°C is recommended to fully melt the excipient.
• At 20-25°C the excipient is not fully crystallized and contains a fraction in liquid state, therefore, it is a semi-solid supplied in block form

  

Tefose® 63 is a non-ionic oil-in-water emulsifier used in topical dosage forms. It contains all the components to easily obtain fine and homogenous emulsions with pleasant texture. Traditionally emulsions are prepared using two surfactants; one with low HLB and one with high HLB. A series of emulsions using different ratios of these surfactants is prepared to determine the ratio at which the emulsion is stable (i.e. corresponding to the required HLB of the system). With Tefose® 63 self-emulsifying base, formulation development and process are much simpler.

See also our new article on Tefose® 63 with a 20 pages product overview and a video here

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