Polymeric excipients ensure the site-specific delivery of the drug at the desired rate for a specified duration to achieve better efficacy. Pharmaceutical excipients were supposed to be pharmacologically inert, and must assure a controlled…

The trend toward products with plant-based ingredients continues to grow as a result of customer demand. ADM can help you with high quality, low toxicity ingredients that are cost-effective, bio-compatible and easily available. In…

Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing and compliance advantages over pellet-filled capsules. However, compaction may negatively affect the release control mechanism of pellets, and subunits…

Parenteral formulation frequently faces limitations associated with drug stability and poor solubility. Drug compatibility and the minimum concentration of drug required to produce the targeted pharmacological effect are key to excipient…

The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound,…

Abstract This feasibility study evaluates a cleaning process designed to avoid the use of detergents and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous manufacturing equipment was cleaned using…

Abstract In the development of drugs misuse and addiction, references are often made to the study of the API (active principle ingredient) as the main cause, which is certainly true, but there is a tendency to overlook the possible role of…

Abstract The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly…