A two-pronged approach against glioblastoma: Drug repurposing and nanoformulation design for in situ‑controlled release

29. March 2023

Glioblastoma (GB) is one of the most lethal types of neoplasms. Its biologically aggressive nature and the presence of the...

Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex Nanogels from Functionalized Hyaluronic Acid

23. March 2023

The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant...

Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations of Polysorbates

12. March 2023

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the...

Ocular Drug Delivery: a Comprehensive Review

25. February 2023

The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted...

Skin drug delivery using lipid vesicles: A starting guideline for their development

23. February 2023

Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It is an...

Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation

22. February 2023

A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson’s disease (PD). Optimization of the SLM microemulsion (ME)...

Transdermal delivery of acemetacin loaded microemulsions: preparation, characterization, in vitro – ex vivo evaluation and in vivo analgesic and anti-inflammatory efficacy

22. February 2023

The goal of this study was to see if microemulsions might be used as a transdermal drug delivery system for...

Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery

14. February 2023

Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract....

Poly(caprolactone)/lignin-based 3D-printed dressings loaded with a novel combination of bioactive agents for wound-healing applications

12. February 2023

Curcumin (CUR) has been shown to possess significant anti-inflammatory properties and significant wound healing potential. Additionally, lignin (LIG) is a...

Formulation and evaluation of ocular self-nanoemulsifying drug delivery system of brimonidine tartrate

10. February 2023

The aim of the current study was to develop an ocular Self-nanoemulsifying drug delivery system (SNEDDS) loaded with Brimonidine tartrate...

Polysorbates