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Captisol
Preparation and Characterization of Clopidogrel Bisulfate-Hydroxypropyl-β-Cyclodextrin Mixed…
The study aimed to increase the intestinal solubility and absorption of orally bioavailable clopidogrel-bisulfate (CPB) by complexing with hydroxypropyl-β-cyclodextrin (HCD) to form a binary inclusion complex that was stabilized by Tween 80 (T80) resulting into mixed inclusion complex. The results…
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Inhaled Therapy for COVID-19: Considerations of Drugs, Formulations and Devices
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the COVID-19 pandemic, has outspread at full tilt across the world. Although several effective vaccines continue to be deployed, reliable antiviral treatments have yet to be developed against this…
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Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery…
Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of…
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Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous…
Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions. Hence, the purpose of this work was to review the strategies that have been used to increase drug strength…
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Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine…
Subcutaneous (SC) ketamine has been found to be effective in pain management, though reports of injection site irritation and sterile abscesses exist with currently available ketamine HCl formulations. Such adverse SC reactions are commonly associated with low pH, high osmolality and/or high…
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The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its Application…
SBECD (Captisol®) with an average degree of substitution of 6.5 sulfobutylether functional groups (SBE = 6.5), is a solubility enhancer for remdesivir (RDV) and a major component in Veklury, which was approved by FDA for the treatment of patients with COVID-19 over 12 years old and weighing over 40 …
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Introducing novel hybridization technique for solubility enhancement of Bosentan formulation
Bosentan is choice of drug for pulmonary arterial hypertension. It belongs to BCS class-II category. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. One cannot unseen the shortcomings of commonly existing solubility…
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Transformation of nanoparticles into compacts: A study on PLGA and celecoxib nanoparticles
Oral delivery of nanoparticles possesses many advantages for delivery of active pharmaceutical ingredients (APIs) to the gastrointestinal tract. However, the poor physical stability of nanoparticles in liquid state is often a challenge. Removing water from the nanosuspensions and transforming the…
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Chitosan/cyclodextrin surface-adsorbed naringenin-loaded nanocapsules enhance bacterial quorum…
Pathogenic bacteria use quorum sensing (QS), a cell-to-cell communication process that uses small signalling molecules, to regulate several essential virulence factors such as bioluminescence, biofilm formation, and bacterial motility. Naringenin, a bitter and colourless flavanone ubiquitous in…
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Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its very low aqueous solubility and poor stability,…
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