A Review On Novel Excipients
ABSTRACT
The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of novel excipients. This review explores the types and examples of novel excipients that have revolutionized drug formulation in recent years. Throughout this review, we delve into the applications, advantages, and limitations of these novel excipients, highlighting their pivotal role in shaping the future of pharmaceutical formulation. The utilization of these innovative materials not only improves drug efficacy and patient compliance but also offers exciting opportunities for personalized medicine and targeted drug delivery.
Table 3: Types of New excipients
| TYPES | EXAMPLE |
|---|---|
| 1. Modified Excipient | Tween™ 80 HP [Croda] Polyplasdone® Ultra [ISP] Kollidon VA 64 Fine [BASF] Swelstar™ Mx1 [Asahi Kasei] GalenIQ™ 721 [Palatinit] |
| 2. Co-processed Excipient | Spectrablend™ HS [Sensient] Prosolv® ODT [JRS] Ludiflash® [BASF] Aquarius® [Ashland] |
| 3. Novel Excipient | Kollicoat® IR [BASF] Soluplus® [BASF] Kollicoat® Smartseal 30 D [BASF] Captisol® [CyDex] |
INTRODUCTION
In addition to the active pharmaceutical ingredient [API], many dosage forms created today are complex systems with numerous extra components. These substances are typically added to active pharmaceutical ingredients in order to:
- Enhance the stability of the formulation: Excipients are incorporated to stabilize the active pharmaceutical ingredient [API], ensuring that the product remains stable over an extended period, thereby extending the shelf life of the dosage form. It is a common observation that pure API tends to lose stability quickly, leading to denaturation or adhering to container walls, making it unsuitable.
- Adjust the formulation for precise dosing in potent medications: When dealing with potent drugs, additional substances are introduced into the formulation to facilitate the creation of an accurate and consistent dosage form.
- Improve patient acceptability: Excipients can play a role in enhancing the acceptability of medications by improving their taste, texture, or other sensory attributes.
- Enhance the bioavailability of active drugs: Excipients, for instance, can contribute to increasing the bioavailability of the active medicinal ingredient. Often, active ingredients like aspirin are poorly absorbed by the human body. In such cases, the active ingredient is either dissolved in or combined with an excipient, which can act as a solvent or aid in the absorption of the drug by the body.
- Ensure the overall safety and effectiveness of the formulation during storage and usage. Excipients are often referred to as these components, and the worldwide pharmaceutical excipient council defines excipient as “Any substance other than active drug or pro-drug that is included in the manufacturing process or is contained in finished pharmaceutical dosage forms”
The following are the excipient’s ideal qualities:
- Possessing chemical stability,
- Demonstrating non-reactivity,
- Exhibiting low sensitivity to equipment and processes,
- Maintaining inertness within the human body,
- Showing non-toxic characteristics,
- Having acceptable sensory properties,
Proving efficient and cost-effective for the intended purpose. [1-5]
Download the full paper as PDF here: A Review On Novel Excipients
or read it here
Article in International Journal of Research in Pharmaceutical Sciences · September 2023, J. in Pharm. Sci., 2023, Vol 1, Issue 9, 304-320 | Review, Vaibhav B. Gunjal, Darshan S. Sonawane, Samruddhi K. Ahire, Pranav K. Jadhav, Yashashri K. Deore, Shivaraj P. Jadhav, Dhananjay M. Patil, Divine College of Pharmacy, Satana, Nashik, Maharashtra, India, 423301.DOI: 10.5281/zenodo.8344687, Published: 14 Sept 2023, Accepted: 11 Sept 2023, Received: 09 Sept 2023
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