The Heated Die on the STYL’ONE Evo Compaction Simulator

The Heated Die on the STYL’ONE Evo compaction simulator is a new powerful feature to assess temperature influence on tablet quality attributes.
It has been designed and developed to improve knowledge in tableting technology by predicting the effects of rising temperature occuring during tablet production. This temperature rise during tableting results from particle deformation, friction, and heat transferred from the machine’s mechanical movement to the product.

Understanding at the R&D stage how temperature affects tablet quality attributes —such as hardness, disintegration, dissolution, and API stability— and how to predict sticking and picking on the tablet, is essential for successful formulation development and effective troubleshooting.

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Thanks to an intuitive control panel and accurate temperature setting from room temperature up to 60°C, the Heated Die makes it easy to integrate temperature into a Quality by Design approach.

The Heated Die Holder is compatible with any D-type die, allowing to easily test or troubleshoot all common tablet shapes and sizes.

Upgrade your existing or new STYL’One Evo Compaction Simulator with this feature to expand your capabilities. With the upgraded software, the temperature can be monitored in real time as additional process parameter for each tablet produced.

By predicting temperature-related issues like sticking or picking during R&D, robust formulations can be developed and appropriate tablet design and/or tooling coatings can be selected — leading to more efficient production, reduced downtime, fewer rejected tablets, and less frequent tooling cleaning.

Even if sticking is not occurring, temperature can have a significant impact on tablet characteristics. Increased hardness is one of the most noticeable effects. The same compaction force could lead to different tablet hardness.
Temperature can also alter material state and ductility, which may reduce porosity and increase solid fraction.
A temperature rise can have an impact on the disintegration properties of a tablet formulation affecting the water absorption process and ultimately the disintegration time.
An increase in the disintegration time of the tablet and/or granules affects the API dissolution time and leads to modifications in dissolution profiles.

The Heated Die is a powerful and essential feature for developing robust tablet formulations, enabling temperature assessment in experimental protocols during development or for production troubleshooting.

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