PMC Isochem

Abstract Purpose Treating posterior segment diseases presents significant challenges because of the intricate anatomical and physiological barriers within the eye...

Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility....

The upper airways represent the point of entrance from where Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to...

Due to their unique characteristics, microemulsions (ME) represent one of the most promising delivery systems which can conquer poor ocular...

Abstract Sorafenib (SFN) is an anticancer multi-kinase inhibitor with great therapeutic potential. However, SFN has low aqueous solubility, which limits...

Abstract Vaccination has emerged as the most effective strategy to confront infectious diseases, among which is leishmaniasis, that threat public...

Abstract Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and...

Abstract The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various...

Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug...

Abstract Aim: This study aim to develop doxycycline within the D-α-tocopheryl polyethylene glycol 1000 succinate micelle platform as an anticancer...