Lubrication Empirical Model to Predict Tensile Strength of Directly Compressed Powder Blends

A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a pre-requisite for simulation of the compaction unit operation where a linkage from tablet press operating parameters and formulation material properties to output tensile strength is required. The approach extends the previously published Kushner and Moore approach to allow calculation across range of solid fractions. The applicability of the approach is supported by testing using formulations with different commonly used pharmaceutical excipients. Continue Lubrication Empirical Model to Predict Tensile Strength of Directly Compressed Powder Blends

Keywords Continuous Manufacture, Scale-Up, In-Silico, Model, Lubrication, Tensile Strength, Compression Pressure