Recent advances in colon drug delivery systems

As a result of its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research of growing interest. Developing new pharmaceutical formulations capable of reaching the colon requires a broad knowledge of natural and synthetic/semisynthetic polymers.

Highlights

• Colon drug delivery is a promising approach but is a difficult challenge to achieve.

• Most common and recent materials for colon drug delivery are described.

• Technologies for developing colon drug delivery systems are reviewed.

• New combinations and innovative technologies arise for specific site drug delivery in the colon.

• Colon drug delivery systems are a promising tool to enhance peptide and protein bioavailability.

Chitosan, polyethylene-oxide, hydroxypropyl methylcellulose, pectin, natural gums, alginates and polymethacrylates have shown promise when applied in the development of colon drug delivery systems, which range from classic formulation strategies such as tablets and capsules to more sophisticated approaches like nanosystems and integrated osmotic-like formulations. This work aims to bring together knowledge regarding the materials and processes used in the development of such pharmaceutical formulations, as well as to highlight recent advances in the field. More on recent advances in colon drug delivery