Formulation Design and characterization of Antifungal Emulgel for Topical Delivery

Emulgel is the latest generation in novel drug transport device used for manage launch of emulsion and gel for the reason of topical use. The steadiness of emulsion is increased, while it is integrated into gel. Miconazole is an antifungal drug has been used inside the remedy of dermatophytic infection. The aim of the existing look at was to formula design and characterization of antifungal emulgel to incorporate hydrophobic or poorly water-soluble drug in formulation and brought via gels and in an effort to increase skin penetration of drug. The gelling component Carbopol 934 is utilized in extraordinary attention in the system of Miconazole emulgel.

Further, for oil phase instruction liquid paraffin as oil, span 20 as emulsifier is used and for aqueous section propylene glycol as co-surfactant, tween 20 as emulsifier, methyl paraben & propyl paraben as preservative is used. The pH of emulgel become adjusted to 6- 6.4 the use of triethanolamine (TEA). Miconazole acts by inhibiting the fungus from producing ergosterol, the fungal equivalent of LDL cholesterol, which will increase membrane fluidity and inhibits fungus increase. The organized emulgel were evaluated for his or her bodily appearance, pH determination, viscosity, spreadability.

The in-vitro diffusion and drug content material research have been executed for all formulations. Physical characteristics of all the prepared emulgel have been desirable. When compared to all different formulations, the method batch F6 suggests higher drug release.

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Excipients used in the study: Carbopol 934, Tween 20

Pranali R. Gajbhiye, Yogesh N. Gholse, Rahul V. Jadhav, Nitin B. Kohale, Formulation Design and characterization of Antifungal Emulgel for Topical Delivery, Pranali R. Gajbhiye, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 118-128 | Research, INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES, Journal Homepage: https://www.ijpsjournal.com

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