Design And Characterization Of Barberine Liquisolid Compacts For Escalating Bioavailability And Antidiabetic Potential: In Vitro,In Vivo And In Silico Approach

The current investigation aimed to develop a barberine (BRN) loaded liquidsolid compact (SLC) to improve the oral therapeutic effectiveness of BRN. full factorial design was employed and the effect of the carrier:coating ratio (X1) and neusilin :corn starch ratio (X2) was systematically investigated on percentage cumulative drug release (Y1) and disintegration time (Y2). In total, 09 experimental runs (SLC–1 to SLC–9) were prepared, evaluated, and converted to solid free-flowing granules using neusilin® US2. SLC–6 comprising labrasol and neusilin : corn starch ratio 8:2 quick disintegration time 58.54±2.59 sec. and higher cumulative drug release 98.12±2.53. FT-IR spectra showed no incompatibilities, whereas DSC results confirmed the amorphous state and molecular dispersion of BRN in liquidsolid compact.

In vitro dissolution studies demonstrated significant (P<0.05) improvement in BRN release characteristics from BRN liquidsolid compact (SLC–6). In-silico studies confirmed hydrogen bond interaction between an oxygen group of BRN and neusilin hydrogen. SLC–6 showed significant (P<0.05) antidiabetic activity when compared to pure BRN and standard acarbose conformed by α-amylase inhibitory and α-glucosidase inhibitory Assay. Remarkably, a 8-fold increase in bioavailability was observed after oral administration of BRN LSC–6 than plain BRN. Thus, BRN liquidsolid compact could be utilized as a potential carrier for BRN delivery in treatment of diabetis.

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Materials

Barberine was procured from Sigma aldrich Pvt. Ltd. Mumbai, India. Labrasol, Kolliphor, Kollisolv and Cremophor-RH-40, were gift samples given to us by Gattefosse in Mumbai, India. Fuji Chemicals Japan has been kind enough to send over a sample of Neusilin US2 as a present. We purchased Tween 20, Tween 80, PEG 400 and double-distilled water from Unique Chemicals in Kolhapur, India. In this research, analytical-grade chemicals have been utilized.

Mohan D.Dhere, E.Bhavya, Design And Characterization Of Barberine Liquisolid Compacts For Escalating Bioavailability And Antidiabetic Potential: In Vitro,In Vivo And In Silico Approach, Department of Pharmacy Practice, Vels University,Pallavaram, Chennai, India, Ph.D Research Scholar, Vels University, Pallavaram, Chennai, India Email
E.Bhavya Vels University,Pallavaram, Chennai, DOI: 10.47750/pnr.2022.13.S09.1098