Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application

Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a lot of attention in recent years. This paper aims to provide an overview of recent advances in the field of biopolymer-based mucoadhesive drug delivery systems for oral application. The primary objectives are to explore the innovations in formulation techniques, discuss strategies to enhance mucoadhesive properties, and highlight the potential of these systems for targeted drug delivery within the gastrointestinal tract. Nanoparticles, microspheres, and hydrogels have recently been integrated into biopolymer-based mucoadhesive drug delivery systems. These novel approaches enable controlled drug release, improve drug bioavailability, and enhance the targeting of specific mucosal tissues.

Recent advances in biopolymer-based mucoadhesive drug delivery systems demonstrate their potential to overcome the challenges associated with oral drug delivery. These systems have shown promise in enhancing drug bioavailability, targeting specific sites within the gastrointestinal tract, and improving patient compliance. Continued research and innovation in this field are expected to drive further improvements in drug delivery technology and its application in the pharmaceutical industry, ultimately benefiting patients and healthcare providers alike. This article provides a summary of biopolymer-based mucoadhesive drug delivery systems for oral administration and explores some of the fundamental ideas that researchers can use to resolve the challenges presented by formulation design.

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Excipients mentioned in the article beside others: chitosan, Carbopol 934, HPMC, Eudragit, PVA, PEG

Rishav Sharma, Suraj Kumar, Rishabha Malviya, Bhupendra G. Prajapati, Dinesh Puri, Sontaya Limmatvapirat, Pornsak Sriamornsak, Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application,
Journal of Drug Delivery Science and Technology, 2023, 105227, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2023.105227.

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