Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer

The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning.

Highlights

N-Carboxymethyl chitosan/poly(ε-caprolactone) core-shell fibers were produced.

Nickel ferrite and Doxorubicin were loaded into the nanofibers against breast cancer.

The sustained release of DOX from core-shell fibers was obtained during 25 days.

The external magnetic field and pH of 5.4 resulted in DOX release during 7 days.

Maximum cytotoxicity was 83 % using CMC/PCL/nickel ferrite 10 % core-shell fibers.

Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5–2.5 kV/cm), CMC concentration (4−6 wt.%) and PCL concentration (8−12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis.

The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF.

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Article Information: Mahdi Abasalta, Azadeh Asefnejad, Mohammad Taghi Khorasani, Ahmad Ramazani Saadatabadi. Carbohydrate Polymers, Volume 257, 2021. https://doi.org/10.1016/j.carbpol.2021.117631.