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Formulation and evaluation of floating tablet of esomeprazole by using natural gums
Formulation and evaluation of floating tablet of esomeprazole by using natural gums
Abstract
Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a controlled manner with less drug administration frequency, and increase the bioavailability of esomeprazole magnesium trihydrate.
Methods: In the current investigation, sodium bicarbonate was used as a gas-generating agent to create effervescent Esomeprazole magnesium trihydate floating tablet formulations. Natural polymers like moringa gum, Azadirachta indica gum, sodium alginate, xanthan gum were used in the formulation of the tablets, which were made utilizing direct compression technology.
Results: All of the developed formulations showed good In vitro buoyancy. The tablets remained buoyant for 12 hours. The drug release profiles revealed that Moringa gum tablets had a more uniform and regulated release, releasing 96% of the drug. In comparison, neem gum tablets released 89% of the drug, xanthan gum tablets released 93%, and sodium alginate tablets released 96%.
Conclusion: Out of all the formulations developed, the F1 formulation had the highest In vitro dissolution results compared to the other batches, exhibiting the requisite sustained release time and acceptable floating qualities.
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Materials and methods
Table 1 List of Material
| Sr. No. | Materials | Supplied by |
|---|---|---|
| 1 | Esomeprazole magnesium trihydrate | Smart Laboratories Pvt. Ltd. (Gift sample) |
| 2 | Xanthan Gum | Yucca Enterprises Mumbai |
| 3 | PVP K 30 | Research Lab Fine Chem Industries Mumbai |
| 4 | Carbopol 120 | Research Lab Fine Chem Industries Mumbai |
| 5 | Sodium bicarbonate | Research Lab Fine Chem Industries Mumbai |
| 6 | Magnesium stearate | Research Lab Fine Chem Industries Mumbai |
| 7 | Talc/ Talcum powder | Chemdyes Corporation Gujarat |
| 8 | Sodium alginate | Research Lab Fine Chem Industries Mumbai |
| 9 | Azadirachta indica gum | Obtained from bark of the plant Azadirachta indica |
| 10 | Moringa gum | Obtained from bark of the plant Moringa oleifera Lam. |
AISHWARYA VINOD GHADGE, SAKSHI ANNA GHARAT, SWAPNIL DILIP PHALAK, VISHAL SHARAD, BODKE, ADITI DEEPAK GAVAND, DARSHANA DILIP GANVIR and DEEPTI BALKRUSHNA GAIKWAD, Formulation and evaluation of floating tablet of esomeprazole by using natural gums, World Journal of Advanced Research and Reviews, 2024, 22(02), 1895–1907, Publication history: Received on 18 April 2024; revised on 25 May 2024; accepted on 28 May 2024, Article DOI: https://doi.org/10.30574/wjarr.2024.22.2.1643
Read also our introduction article on Magnesium Stearate here:
