Medium-Dosage Paracetamol Formulation with PROSOLV® RX 90 – Case Study II

What is PROSOLV® RX 90?

PROSOLV® RX 90 was developed using JRS PHARMA‘s proven PROSOLV® Technology and was the first lubricated high functionality excipient (HFE) on the market. PROSOLV® RX 90 is an all-in-one, ready-touse excipient composite. It effectively combines all functionalities required for tableting in a single excipient composite.

PROSOLV® RX 90 is more than a simple physical blend. It is a homogeneous, lubricated high functionality excipient composite. Each component of the composite maintains its chemical identity while synergistically providing increased functional performance.

See the case study:

Case Study II: Medium-Dosage Paracetamol Formulation

In these formulations, the properties of the API dominate the formulation and compaction properties. A formulation containing 40 % Paracetamol as a poorly compressible model API was evaluated to investigate the compaction properties of PROSOLV® RX 90 in a challenging formulation.

Case study: poorly compressible API
PROSOLV® RX 90 + paracetamol tablets (13 mm, 500 mg) were pressed on a
IMA Kilian – Pressima 13 EU-D.

Conclusion

The analyzed tablets showed significantly improved tablet properties in comparison to the tablets made from the physical blend.

PROSOLV® RX 90 tablets exhibited:

• 30 – 50 % higher robustness (tensile strength)
• 100 % higher lubrication effciency on average
• Similar dissolution profiles for both products

Benefits

• The PROSOLV® RX 90 line is especially well suited for continuous manufacturing
• Only 2 feeders are needed – one for the API – one for the PROSOLV® RX 90 composite which acts as filler/binder, flow aid, disintegrant and lubricant at the same time
• Unique surface structure enables fast and segregation-free blending with API’s
• Outstanding robustness in terms of blending time, especially for the SSF containing PROSOLV® RX 90.

See the full technical brochure on PROSOLV® RX 90 here

(click the picture to download the brochure)

Source: JRS Pharma technical brochure PROSOLV® RX 90

Read also the other PROSOLV® RX 90 case studys:

• Case Study I: Improving Content Uniformity in Low-Dose DC Formulations
• Case Study III: High-speed Tableting of PROSOLV® RX 90

If you have any questions or need a sample by JRS Pharma, please feel free to contact us: