High-speed Tableting of PROSOLV® RX 90 – Case Study III

What is PROSOLV® RX 90?

PROSOLV® RX 90 was developed using JRS PHARMA‘s proven PROSOLV® Technology and was the first lubricated high functionality excipient (HFE) on the market. PROSOLV® RX 90 is an all-in-one, ready-touse excipient composite. It effectively combines all functionalities required for tableting in a single excipient composite.

PROSOLV® RX 90 is more than a simple physical blend. It is a homogeneous, lubricated high functionality excipient composite. Each component of the composite maintains its chemical identity while synergistically providing increased functional performance.

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Case Study III: High-speed Tableting of PROSOLV® RX 90

Introduction

The reduction of tablet manufacturing costs has become increasingly important for the pharmaceutical industry. One of the ways to save production costs is to increase the speed of tableting to produce more tablets in the same amount of time. An improvement of the tableting process often requires the need to simplify the formulation through the use of high functionality excipients. The lubricated high functionality excipient PROSOLV® RX 90 provides the necessary robustness and consistency of tablet manufacturing, leading to increased production effciency and tremendous cost savings.

PROSOLV® RX 90 and the corresponding physical blend of the single components were compared in high speed compression on a FETTE 2090i tablet press. Paracetamol was used as a model API in a dose of 40 %. The tablet characteristics, as well as the production costs, were compared.

Conclusion

• PROSOLV® RX 90 converts technical benefits into commercial success.
• PROSOLV® RX 90 is ideally suited for high-speed tableting equipment.
• Faster tablet production leads to more effcient output.
• In this case study a 300 % increase in production speed led to 2/3 cost reduction.
• PROSOLV® RX 90 is a great way to increase capacity without investing in new buildings and machines and adapt to increased market demands quickly without capital risk.

Advantages of PROSOLV® RX 90 in Continuous Tablet Manufacturing

Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing.
Multifunctional excipients, such as PROSOLV® RX 90, may be particularly well-suited for continuous
processes because of three of their unique features:

1. All-in-one composite

A typical tablet formulation consists of at least one API, a filler/binder, a disintegrant, and a lubricant. Thus, even a simple formulation consists of at least four ingredients to be accurately fed into the continuous manufacturing system.The use of multifunctional excipients will therefore, be advantageous. PROSOLV® RX 90 especially stands out in terms of combining all the required blend functionalities into a single co-processed excipient. Using PROSOLV® RX 90 reduces the number of necessary feeder units to just two, one for the active ingredient and one for the excipient composite.

2. Blend uniformity

Achieving high blend uniformity is essential for any tableting manufacturing process, be it batch or continuous. In continuous processes, blending is particularly demanding, because in comparison to batch processes, dwell times in the blender are limited. The blending advantages of PROSOLV® products are outstanding, due to their unique surface structure, enabling good homogeneity even for low dose APIs via interactive blending.

3. Blending robustness

Another critical aspect of blending is the risk of overlubrication resulting from excessive blending. Therfore, it is advantageous to select lubricants for continuous manufacturing, which are less sensitive to blending times and conditions or to choose all-in-one excipient. Composites, such as PROSOLV® RX 90 contain the particle lubricant within their unique structure and are less sensitive towards overlubrication.

See the full technical brochure on PROSOLV® RX 90 here

(click the picture to download the brochure)

Source: JRS Pharma technical brochure PROSOLV® RX 90

Read also the other PROSOLV® RX 90 case studys:

• Case Study I: Improving Content Uniformity in Low-Dose DC Formulations
• Case Study III: Medium-Dosage Paracetamol Formulation

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