Improving Content Uniformity in Low-Dose DC Formulations with PROSOLV® RX 90- Case Study I

What is PROSOLV® RX 90?

PROSOLV® RX 90 was developed using JRS PHARMA‘s proven PROSOLV® Technology and was the first lubricated high functionality excipient (HFE) on the market. PROSOLV® RX 90 is an all-in-one, ready-to-use excipient composite. It effectively combines all functionalities required for tableting in a single excipient composite.

PROSOLV® RX 90 is more than a simple physical blend. It is a homogeneous, lubricated high functionality excipient composite. Each component of the composite maintains its chemical identity while synergistically providing increased functional performance.

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Case Study I: Improving Content Uniformity in Low-Dose DC Formulations

Introduction

Direct compression of low dosage APIs often leads to content uniformity issues. The unique PROSOLV® Technology used to produce PROSOLV® RX 90 creates a significant increase of the specific surface area compared to the physical blend. This, along with its micro-rugosity, promotes high content uniformity when using low dosage APIs.

Piroxicam direct compression tablets

Benefits of PROSOLV® RX 90

Simplify tableting

Traditional tablet production methods include dry granulation, wet granulation, and direct compression. Granulation processes are typically complex, requiring a great deal of equipment, human resources, and time. The lengthy, multi-stage process leaves room for error, and thus, batch losses. Direct compression is a shorter, and often preferred, production process. It requires fewer resources than wet granulation and leaves less room for error and batch loss (Figure 3).

The PROSOLV® RX 90 line includes all the necessary excipients for direct compression in an all-in-onecomposite.
Simply add the APIs, blend and compress into tablets. This easy method of tableting allows for shorter development times and lower R&D costs, leading to faster time to market. The outstanding compaction properties enable smaller tablet sizes, faster production and may boost profitability due to prolonged tooling life. With PROSOLV® RX 90, buy, analyse and store only one excipient instead of five, thus reducing storage and quality control costs.

See the full technical brochure on PROSOLV® RX 90 here

(click the picture to download the brochure)

Source: JRS Pharma technical brochure PROSOLV® RX 90

Read also the other PROSOLV® RX 90 case studys:

• Case Study II: Medium-Dosage Paracetamol Formulation
• Case Study III: High-speed Tableting of PROSOLV® RX 90

If you have any questions or need a sample by JRS Pharma, please feel free to contact us: