MEGGLE’s MicroceLac® Plus – A new benchmark in tabletability by outperforming conventional DC excipients

MicroceLac® Plus

The new co-processed Excipient for Direct Compression (DC)

What’s new? What’s special?

MicroceLac® Plus is an innovative addition to the MEGGLE co-processed excipients line, combining 35% alpha-lactose monohydrate and 65% microcrystalline cellulose (MCC) to enhance tablet formulations. This CPE offers a remarkable set of advantages, most notably its superior tabletability! It achieves tablet hardness that exceeds not only its individual components and their physical mixture but also standard DC excipients.

Designed for direct compression, MicroceLac® Plus is ideal for production of robust tablets with high mechanical strength and low friability, even with challenging APIs or high drug loads. MicroceLac® Plus is the next level excipient for those who want to be sure of superior performance.

Benefits

Outstanding tabletability: Outperforming all standard excipients on the market
Enables direct compression, even for difficult active ingredients or high drug load
High tablet hardness and very low friability also at high drug loads
Synergistic effect: Tabletability of CPE even better than for single ingredients
Good flowability in comparison with its corresponding physical blend
No capping tendency due to ideal combination of plastic and brittle deformation
Very smooth surface of the resulting cores for easy and economical coating
Constant lactose/cellulose ratio: Simple and consistent dosing also in continuous manufacturing
Reduction of tablet size: Ideal for manufacturing of easy-to-swallow, patient-friendly dosage forms

Areas of Application

Primarily designed for direct compression (DC) and continuous direct compression (CDC).
Direct compression of difficult APIs
Formulations with a high API content
Suitable for mini-tablets
Easy and economical coating

Particle size distribution (PSD) & Additional typical values

(click to enhance)

Analyzed by Hosokawa Alpine air-jet siever.

Tabletability Profile

Comparing the tabletability profile of MicroceLac Plus to MicroceLac 100, which already offers exceptional performance, underlines the premium quality of MicroceLac Plus in terms of achievable tensile strength by applied compaction pressure.

Tabletability Profile

Thanks to its unique intra-particular structure, MicroceLac Plus delivers still significant exploitable residual porosity (solid fraction <= 0.85) up to even high tensile strength of > 5 MPa