All4Nutra
MicroceLac® Plus
The new co-processed Excipient for Direct Compression (DC)
What’s new? What’s special?
MicroceLac® Plus is an innovative addition to the MEGGLE co-processed excipients line, combining 35% alpha-lactose monohydrate and 65% microcrystalline cellulose (MCC) to enhance tablet formulations. This CPE offers a remarkable set of advantages, most notably its superior tabletability! It achieves tablet hardness that exceeds not only its individual components and their physical mixture but also standard DC excipients.
Designed for direct compression, MicroceLac® Plus is ideal for production of robust tablets with high mechanical strength and low friability, even with challenging APIs or high drug loads. MicroceLac® Plus is the next level excipient for those who want to be sure of superior performance.
Benefits
- Outstanding tabletability: Outperforming all standard excipients on the market
- Enables direct compression, even for difficult active ingredients or high drug load
- High tablet hardness and very low friability also at high drug loads
- Synergistic effect: Tabletability of CPE even better than for single ingredients
- Good flowability in comparison with its corresponding physical blend
- No capping tendency due to ideal combination of plastic and brittle deformation
- Very smooth surface of the resulting cores for easy and economical coating
- Constant lactose/cellulose ratio: Simple and consistent dosing also in continuous manufacturing
- Reduction of tablet size: Ideal for manufacturing of easy-to-swallow, patient-friendly dosage forms
Areas of Application
- Primarily designed for direct compression (DC) and continuous direct compression (CDC).
- Direct compression of difficult APIs
- Formulations with a high API content
- Suitable for mini-tablets
- Easy and economical coating
Particle size distribution (PSD) & Additional typical values
(click to enhance)
Tabletability Profile
Comparing the tabletability profile of MicroceLac Plus to MicroceLac 100, which already offers exceptional performance, underlines the premium quality of MicroceLac Plus in terms of achievable tensile strength by applied compaction pressure.
Thanks to its unique intra-particular structure, MicroceLac Plus delivers still significant exploitable residual porosity (solid fraction <= 0.85) up to even high tensile strength of > 5 MPa
Microporous Structure
MicroceLac® Plus features a unique intraparticular microporous structure that supports the exceptional tableting capabilities of the material.
Packaging & Retest Date
See the full technical brochure and flyer on MicroceLac® Plus here
Technical brochure MicroceLac® Plus
(click the picture to download the brochure)
Source: MEGGLE technical brochure and flyer on MicroceLac® Plus
