Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Proposing a model study, this research shows how most of the professed energetically stable systems are actually energetically unstable, subjected to indiscriminate and false characterization, leading to significant effects for their pharmaceutical applications. A self-emulsifying drug delivery system (SEDDS) was developed and then solidified (S-SEDDS) using a model drug finasteride. Physical nature of SEDDS was identified by measuring simple dynamics which showed that the developed dispersion was thermodynamically unstable. An in vivo study of albino rats showed a three-fold enhanced bioavailability of model drug with SEDDS as compared to the commercial tablets. The study concluded that measuring simple energy dynamics through inherent properties can distinguish between thermodynamically stable and unstable lipidic systems. It might lead to correct identification of a specific lipidic formulation and the application of appropriate characterization techniques accordingly. Future research strategies include improving their pharmaceutical applications and understanding the basic differences in their natures.
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Materials
Finasteride was a kind gift from Ferozsons Laboratories limited, Pakistan. Labrafil M 1944 CS and Labrafil M 2125 CS as long chain triglycerides (LCT), Capryol 90, Capryol PGMC and Labrafac lipophile WL 1349 as medium chain triglycerides (MCT) (Gattefosse, France). Soyabean oil, olive oil and coconut oil were purchased from local market. Triacetin as short chain triglyceride (SCT) (Alfa Aesar, Germany), Cremophore (RH 40), Tween-80 (Sigma Aldrich, Germany), PEG 400 (Bio-Labs, Islamabad). All the chemical and solvents used were of analytical grade.
Rehman, F.U.; Farid, A.; Shah, S.U.; Dar, M.J.; Rehman, A.U.; Ahmed, N.; Rashid, S.A.; Shaukat, I.; Shah, M.; Albadrani, G.M.; Kamel, M.; Altyar, A.E.; Abdel-Daim, M.M.; Shah, K.U. Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability. Pharmaceuticals 2022, 15, 1064.
https://doi.org/10.3390/ph15091064