Sustainably sourced Squalene – by Croda
Non-shark derived, engineered by synthetic biology. Our pharmaceutical-grade Squalene has superior purity, naturally setting it apart on the market.
An innovative alternative to shark-derived squalene using synthetic biology
There is a significant need for a highly purified alternative to shark-derived squalene to meet the requirements of the vaccine industry. To mitigate the devastating impact on deep-sea shark populations, we are proud to offer a sustainably sourced Squalene carrying the same benefits as
shark-derived squalene.
Pharmaceutical grade Squalene using synthetic biology
Produced using cutting-edge technology that centres on synthetic biology, our pharmaceutical-grade squalene has superior purity, naturally setting it apart on the market. Fermentation based, our Squalene uses yeast isoprenoid pathway engineering, through proprietary technology developed by Amyris. Our purification excellence enables access to a highly purified grade for human and veterinary applications.
What is squalene? And why is there a strong need for vaccine formulations?
Squalene is an organic compound with powerful bioactive properties1. As a naturally occurring oil, squalene has successfully been used in various emulsion-based vaccine adjuvant formulations. They do not only initiate potent innate and adaptive immune responses2 but also have established safety records. This has ignited interest in squalene and inspired the search for more sustainable alternatives.
Squalene-based emulsions
Squalene-based emulsions are used in licensed seasonal and pandemic influenza vaccines. Furthermore, there are clinical development projects for prophylactic vaccines ongoing, for example those against tuberculosis, shingles, schistosomiasis, HIV and other severe diseases, combining squalene with a TLR4 agonist in their emulsion adjuvant.
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Source: Croda, website Sustainably sourced Squalene | Croda Pharma