Tablet in Capsule Technology – Overview

Tablets are solid dosage forms containing medicinal substances with or without suitable diluents. They are the most widely preferred form of medication both by pharmaceutical manufacturer as well as physicians and patients. Capsules are solid dosage forms in which drug is enclosed within either a hard or soft soluble shell. The shells are generally made up of gelatin. The capsules may be regarded as the container drug delivery system for powder and non-powder filling such as tablets, capsules and pellets. Tablet in capsule is a multifunctional and multiple unit system, which contains versatile mini-tablets in a hard gelatin capsule.

It can be developed by preparing Rapid release Mini-Tablets, Sustained-release Mini-Tablets, Pulsatile Mini-Tablets, and Delayed-onset Sustained-release Mini-Tablets, each with various lag times of release and encapsulating in a capsule. Biphasic delivery system can be achieved in this dosage form and it can produce the rapidon set of release for those drugs that need prompt appearance of the rapeutic effect, followed by an extended release phase at a constant rate.MP formulations generally have a more reliable in-vivo dissolution performance when compared to a single unit dosage form, resulting in more uniform bioavailability and clinical effect. The rationale of mini tablets formulation is to accomplish several releases in one formulation by combining altered dose.

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