Hayashibara Trehalose SG – Injectable Grade

Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose

Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative research. Utilizing our technological background in biotechnology and in-depth knowledge of saccharide production, Hayashibara became the first company in the world to succeed in the mass production of “Trehalose”, a unique disaccharide recognized as a beneficial excipient for the biopharmaceutical industry. In addition to trehalose, Hayashibara has been supplying for many years other high purity ingredients to the pharmaceutical industry worldwide.

TREHALOSE SG JP, USP-NF, Ph.Eur., CP – Injectable grade

General

Trehalose is a dihydrous crystalline and non-reducing disaccharide consisting of two glucose molecules linked by an α,α‒1,1 bond.

TREHALOSE SG is monographed as being low endotoxin and is intended mainly for injection. Because of its stability it can be autoclave or filter sterilized.

Hayashibara Trehalose SG - general — Hayashibara Trehalose SG – general

Properties

Protects the quality of products during processing due to its non-reactivity. TREHALOSE SG does not participate in the Maillard reaction, preventing the development of undesired colors, odors and flavors.
Heat and acid resistant (pH 2 and 100̊C for 24 hours)
Stable amorphous phase under high temperature due to its high glass-transition temperature (Tg：approximately 120℃). TREHALOSE SG can be used as a stabilizer for biomaterials due to its protective effect against environmental temperature variations.

Stabilization of biomaterials

Proteins can be denaturized by stressors such as heat, shear, and phase change during processing or storage. TREHALOSE SG can replace the water molecules that is closely associated with proteins, stabilizing the higher-order structure to prevent denaturation, especially during heating, freezing or lyophilization
TREHALOSE SG modifies ice crystal development to reduce damage to cells and proteins during freezing.

See the full brochure on “Trehalose SG – Injectable Grade” here

(click the picture to download the brochure)

Source: Hayashibara brochure “Trehalose SG – Injectable Grade”

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