Advancing the Science of TUPs Management: Improved Process Controls, Enhanced Testing Methods and Building a Leading Brand
Off colored particles, also known as technically unavoidable particles (TUPs) or black specks, have presented challenges for pharmaceutical customers and excipient suppliers for decades. An inherent variability of standard testing and the lack of a common measurement method across the industry exacerbates this issue. Even today, the reduction of TUPs remains a common goal for customers because of the possibility of batch failures and the waste of expensive end tablet product. DuPont has worked to tackle this challenge. An extension of its market-leading Pharma Grade Avicel® microcrystalline cellulose (MCC) excipients offers a standard lower TUPs profile. Through increased investment in advanced technologies and capabilities, we’re able to measure TUPs in Avicel® MCC in a more consistent, repeatable and dependable way. This Avicel® LS line does not require re-qualification for existing Avicel® customers; it is a convenient option for customers looking to reduce TUPs visible in their products.
Download the white paper here: Advancing the Science of TUPs Management
