Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioeq

Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies

24. April 2023

The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a...

Use of a Platform Formulation Technology to De-Risk Solid-State Variation in Drug Development

21. April 2023

Active pharmaceutical ingredients (APIs) can exist in multiple crystal forms, known as polymorphs, that are chemically identical. Polymorphs of an...

Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by hot-melt extrusion

7. April 2023

Hot-melt extrusion (HME) is a technology increasingly common for the commercial production of pharmaceutical amorphous solid dispersions (ASDs), especially for...

Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and supersaturation in the digestive aqueous phase

7. April 2023

Understanding and controlling the drug solubilization in digestive environment is of great importance in the design of lipid based solid...

Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation optimization and characterization of enhanced properties

5. April 2023

Sorafenib, marketed under the brand name Nexavar®, is a multiple tyrosine kinase inhibitor drug that has been actively used in...

3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

29. March 2023

Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid...

Flowability, binding and release property of “self-lubricating” microcrystalline cellulose

10. March 2023

Microcrystalline cellulose (MCC) has been widely used as an excipient in tablets. Silicified microcrystalline cellulose (SMCC) has more application than...

AEROPERL® 300 Pharma – Improving the dissolution of poorly soluble APIs

10. March 2023

AEROPERL® 300 Pharma colloidal silicon dioxide: Our solution to the solubility challenge Active pharmaceutical ingredients (APIs) by Evonik in oral...

Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing

3. March 2023

The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in...

Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development, opportunities and printing limitations

15. January 2023

Drop-on-powder 3D printing is able to produce highly drug loaded solid oral dosage forms. However, this technique is mainly limited...

Silicon Dioxide

Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies

Use of a Platform Formulation Technology to De-Risk Solid-State Variation in Drug Development

Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by hot-melt extrusion

Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and supersaturation in the digestive aqueous phase

Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation optimization and characterization of enhanced properties

3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

Flowability, binding and release property of “self-lubricating” microcrystalline cellulose

AEROPERL® 300 Pharma – Improving the dissolution of poorly soluble APIs

Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing

Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development, opportunities and printing limitations

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